Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity
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منابع مشابه
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity
The mechanisms by which melanoma and other cancer cells evade anti-tumor immunity remain incompletely understood. Here, we show that the growth of tumors formed by mutant Braf(V600E) mouse melanoma cells in an immunocompetent host requires their production of prostaglandin E2, which suppresses immunity and fuels tumor-promoting inflammation. Genetic ablation of cyclooxygenases (COX) or prostagl...
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ژورنال
عنوان ژورنال: Cancer Cell International
سال: 2015
ISSN: 1475-2867
DOI: 10.1186/s12935-015-0260-7